Translational Science Model

Translational Science Model

The Knowledge to Action Framework was developed by Dr. Ian Graham and his colleagues in 2006 and was founded on over thirty theories of change. It gives a seven-phase cycle that allows stakeholders to translate knowledge into practice to enhance outcomes (Graham & Tetroe, 2010). The model comprises two essential parts: knowledge generation and action. This model’s primary purpose is to turn evidence into action while monitoring, evaluating, and tweaking the implementation process (Boscart et al., 2020). The seven phases in the Knowledge to Action Framework will serve as a structure and guide for this DNP project.

The first phase of the Knowledge to Action (KTA) model is to identify the problem. The problem should be determined to inform the most appropriate intervention tool. The practice problem, in this case, is an increasing prevalence of obesity which needs urgent intervention. The AHA lifestyle guidelines are a relevant tool that should be implemented to prevent and reduce the prevalence of obesity.

The second phase is to adapt knowledge to the local context. There is a need to identify available stakeholders in the local context, including available healthcare providers, nurse managers, and patients. The stage also involves building a robust infrastructure in the local context and linking the local context to other model locations.

The third phase is to assess facilitators and barriers to knowledge use. This stage involves identifying facilitators to change implementation and the obstacles that may drag the process or reduce the project’s outcomes (Kitson et al., 2018). The location is essential as it helps stakeholders utilize the facilitators and address the barriers. The facilitators include a cooperative patient care team, and the potential wall is participants may forget to input data in the tracking app, and others lack proper mobile access. The challenges can be addressed by educating patients and sending weekly reminders.

The fourth stage is to select, tailor, and implement interventions The step involves mapping the interventions to the context and implementing them in the best way possible. The intervention will be implemented at this stage, and patients will start their journey to apply AHA guidelines and use the tracking app to ensure compliance.

The fifth phase is to monitor knowledge use. Collecting data on knowledge use is essential and providing the service aligns with the project purpose (Bryant et al., 2019). It will help stakeholders make some changes if needed to facilitate the project.

The sixth phase is to evaluate the outcomes. It is vital to assess the effects of the strategy intervention to inform future decisions. Intervention evaluation helps determine if any goals should be addressed to enhance the project outcomes (Zhao et al., 2021). The DNP leader may evaluate the results by interviewing patients and the patient’s care team. Internal sources may also include weight changes, as evident in the clinic’s data.

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Translational science model
Translational Science Model

Phase seven of the KTA model is to sustain knowledge. There should be strategies for supporting evidence-based knowledge to enhance and impact the current practice. Knowledge implementation is more effective if it is maintained for a long time. To sustain long-term weight control, nutrition knowledge, attitudes, and dietary self-regulation are significant predictors of overweight and obesity (Balani et al., 2019).


Balani, R., Herrington, H., Bryant, E., Lucas, C., & Kim, S. C. (2019). Nutrition knowledge, attitudes, and self-regulation as predictors of overweight and obesity. Journal of the American Association of Nurse Practitioners, 31(9), 505–510.

Boscart, V., Davey, M., Crutchlow, L., Heyer, M., Johnson, K., Taucar, L. S., … & Heckman, G. (2020). Effective chronic disease interventions in nursing homes: a scoping review based on the knowledge-to-action framework.  Clinical gerontologist, 1-14.

Graham, I. D., & Tetroe, J. M. (2010). The knowledge to action framework. Models and frameworks for implementing evidence-based practice: Linking evidence to action207, 222.

Kitson, A., Brook, A., Harvey, G., Jordan, Z., Marshall, R., O’Shea, R., & Wilson, D. (2018). Using complexity and network concepts to inform healthcare knowledge translation. International Journal of Health Policy and Management, 7(3), 231.

Zhao, J., Li, X., Yan, L., Yu, Y., Hu, J., Li, S. A., & Chen, W. (2021). Using theories, frameworks, or models in knowledge translation studies in healthcare settings in China: a scoping review protocol. Systematic Reviews, 10(1), 1-7.

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